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Acute (short-term) severe pain (immediate-release tablet only)
Chronic (long-term) severe pain (extended-release tablet only) Oxymorphone dosage forms tablet icon Tablet 5mg 10mg 20mg 40mg Typical dosing for oxymorphone Your provider will work with you to prescribe the right dose of oxymorphone for your individual needs. It's recommended to use the lowest dose possible for the shortest duration of time to manage your pain. Oxymorphone is an opioid that mostly binds to the mu-opioid receptor in the brain to lower your perception of pain. Acute pain (immediate-release tablet) People who don't take opioids regularly: The typical starting dose is 10 mg to 20 mg by mouth every 4 to 6 hours as needed for pain. People switching from another opioid: Your provider will determine the most appropriate dose for you depending on what opioid you were on previously. It is typically taken every 4 to 6 hours. Chronic pain (extended-release tablet) People who don't take opioids regularly: The typical starting dose is 5 mg by mouth every 12 hours (twice a day). People switching from another opioid: Your provider will determine the most appropriate dose for you depending on what opioid you were on previously. It is typically taken every 12 hours (twice a day). Frequently asked questions about oxymorphone. Pros and cons of oxymorphone Pros Generic available Available in both short-acting and long-acting formulations Extended-release formulation provides around-the-clock pain relief Effective at relieving severe pain that has not responded to other alternatives Cons High risk for addiction, abuse, and misuse Needs to be taken on an empty stomach, which may be inconvenient Immediate-release tablet has to be taken multiple times a day (4 to 6 times a day) Can cause withdrawal symptoms if you stop taking suddenly
Pharmacist tips for oxymorphone
Swallow the extended-release tablet whole with a glass of water. Do not chew, break, crush, or tamper with the pill, because doing so can cause too much medication to be released all at once in your body which can put you at risk for serious and fatal side effects. It's best to take oxymorphone on an empty stomach at least 1 hour before or 2 hours after eating. Food can cause more oxymorphone to accumulate in your body which can put you at higher risk for side effects. Avoid driving or other tasks that require you to be alert until you know how this medication affects you. Do not mix oxymorphone with alcohol, sleeping pills, or muscle relaxants. This combination can be deadly and can cause severely low blood pressure, extreme sleepiness, and breathing problems. Talk to your provider or local pharmacist about all the medications you are taking. If you have been taking opioids long-term, do not stop taking them suddenly. You might need to cut back gradually over the course of a few days or weeks. There are risks for abuse, addiction, and misuse with this medication. Make sure to store oxymorphone in a safe place away from children and other people. Oxymorphone can cause a sudden drop in blood pressure when changing positions, such as from sitting to standing. This is especially common when you first start oxymorphone and when the dose is changed. Be careful when changing positions to avoid from falling and hurting yourself.
What are the side effects of oxymorphone?
With any medication, there are risks and benefits. Even if the medication is working, you may experience some unwanted side effects. Contact your doctor immediately if you experience any of the following: Trouble breathing or shortness of breath Fast heartbeat Chest pain Hives Swelling of your face, tongue or throat Extreme sleepiness Increased irritability Increased body temperature Trouble walking Stiff muscles Mental changes such as confusion Caution Small The following side effects may get better over time as your body gets used to the medication. Let your doctor know immediately if you continue to experience these symptoms or if they worsen over time. Common side effects Constipation Nausea Vomiting Sleepiness Fever Headache Dizziness Itching Other side effects Dry mouth Stomach pain Sweating more than normal Fatigue Upset stomach or indigestion Decreased appetite Blurred vision Feeling restless Anxiety Diarrhea Trouble sleeping
What are the risks and warnings for oxymorphone?
Oxymorphone can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options Addiction, abuse, misuse Risk factors: People who have mental health conditions (e.g. depression) | History of or family history of drug abuse Black Box Warning Oxymorphone has a high risk of addiction, abuse, and misuse. Your body can develop tolerance to oxymorphone, which means that more medication is needed to treat the same pain. You may become physically dependent on oxymorphone if you have been using it long-term, which means that you'll feel withdrawal symptoms if you stop taking it suddenly. Withdrawal symptoms can include restlessness, yawning, chills, nausea, vomiting, diarrhea, and increased irritability. Work with your provider to slowly and safely cut back this medication to avoid side effects. Take only the prescribed dose. People with a history of drug abuse shouldn't take oxymorphone if an alternative medication is available. Because of these risks, the FDA has required this medication and all opioids to be under a Risk Evaluation and Mitigation Strategy (REMS) program. This means your provider or pharmacist will talk to you about proper use, serious risks, and appropriate storage and disposal of this medication in order to keep you and your loved ones safe. Medication education programs Black Box Warning Since this medication can cause life-threatening and fatal side effects, the drug companies are required to provide healthcare providers with the resources to properly and safely prescribe this medication. The provider should discuss the risks and benefits with you prior to prescribing this medication to you. Life-threatening breathing problems Risk factors: People age 65 or older | People who are severely ill | People who have lung disease Black Box Warning Oxymorphone can cause irregular or slow breathing that can put you in a coma and can even cause death. Don't take more than what your provider prescribed. Always check with your provider before starting any new medications or supplements. Make sure to take special precautions to store this medication in a safe place away from the reach of children. If a child accidentally uses this medication, they can overdose, develop breathing problems, and have a fatal outcome. If you're concerned with the risk of overdosing with this medication, discuss with your provider about getting a prescription for naloxone (Narcan). Naloxone can help to reverse the effects of opioids and possibly save your life. Harm to your baby Risk factors: Long-term use of oxymorphone during pregnancy Black Box Warning There is a high risk that your newborn baby could develop withdrawal symptoms if you've been using oxymorphone for a long period of time during pregnancy. These withdrawal symptoms can be deadly for infants. If you're pregnant, or think you may be pregnant, talk to your provider about all of the risks that are associated with this medication before starting it. Dangerous interactions with other medications and alcohol Black Box Warning Oxymorphone can interact with other medications, which can change how it affects your body and pain overall. Some medications can increase the concentration of oxymorphone and cause fatal respiratory depression (slowed breathing). Other medications can lower the drug concentration and lead to inadequate control of your pain. Some examples of medications that might interact with oxymorphone include, certain anbiotics, antifungals, and medications used for anxiety or depression. It's also very important to avoid alcohol while on this medication, because the combination can lead to serious side effects such as slowed breathing, low blood pressure, and extreme sedation. While taking oxymorphone, don't start any new prescription or over-the-counter medications until confirming with your provider or pharmacist that it is safe to do so. Serious allergic reactions Oxymorphone can cause serious and life-threatening allergic reactions. If you experience hives, swelling of the face, throat, or tongue, or difficulty breathing while taking this medication, get medical help right away. You will need to stop taking oxymorphone and switch to a different medication. Adrenal problems Risk factors: Using oxymorphone for more than a month Oxymorphone can cause your adrenal glands to not produce the right amount of hormones for your body to function properly. If you experience nausea, vomiting, loss of appetite, fatigue, weakness, dizziness, and low blood pressure while taking this medication, let your provider know. Proper exam by your provider may be required to rule out adrenal problems. Low blood pressure Oxymorphone can cause a sudden drop in your blood pressure. You may feel dizzy and/or lightheaded. If you're sensitive to low blood pressures, change positions slowly, such as going from sitting to standing. If you consistently get low blood pressure symptoms, you may need to try a different pain medication. Head or brain injuries People who have brain or head injuries are at higher risk of developing extreme sedation and breathing problems while taking this medication. Let your provider know about all of your medical conditions prior to starting oxymorphone. People with liver problems Oxymorphone is primarily broken down by the liver. If your liver is not working properly, more oxymorphone can accumulate in your body which can put you at an increased risk for side effects such as breathing problems and excessive sleepiness. Oxymorphone should not be used in people with moderate or severe liver disease. Gastrointestinal (GI) blockage and swallowing issues If you have certain stomach conditions or GI blockage, do not use this medication, because it can worsen your problems. Let your provider know if you experience stomach pain, feeling of fullness in your stomach, or extreme constipation while taking this medication. The extended-release tablet of oxymorphone is known to cause swallowing issues in people taking it. It's very important not to tamper with the tablet (e.g. soaking it in water, licking the tablet) prior to swallowing it. If you have problems swallowing pills, it's best to talk to your provider about trying a different medication.
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