Buy Oxycontin 40mg Medicine Online
Buy oxycontin 40mg medicine online without any prescription. Overnight shipping to the states of the United States and Canada. We are selling best quality of oxycontin 40mg pills. We will deliver your medication at your doorsteps. Purchase oxycontin pills for sale. You will get this medication at a cheap price. We have all kinds of online payment option is available with cash on delivery.
What Is Oxycontin
This medication is used to help relieve severe ongoing pain (such as due to cancer). Oxycodone belongs to a class of drugs known as opioid analgesics. It works in the brain to change how your body feels and responds to pain.The higher strengths of this drug (more than 40 milligrams per tablet) should be used only if you have been regularly taking moderate to large amounts of an opioid pain medication. These strengths may cause overdose (even death) if taken by a person who has not been regularly taking opioids.Do not use the extended-release form of oxycodone to relieve pain that is mild or that will go away in a few days. This medication is not for occasional ("as needed") use.
Dosage Forms & Strengths
capsule, immediate-release: Schedule II 5mg tablet, immediate-release: Schedule II 5mg 10mg 15mg 20mg 30mg abuse deterrent tablet, immediate-release (Oxaydo): Schedule II 5mg 7.5mg Discourages intranasal abuse abuse deterrent tablet, immediate-release (RoxyBond): Schedule II 5mg 7.5mg Creates viscous material if mixed with liquid that does not pass through a needle abuse deterrent tablet, controlled-release (OxyContin): Schedule II 10mg 15mg 20mg 30mg 40mg 60mg 80mg abuse deterrent capsule, controlled-release (Xtampza ER): Schedule II 9mg (equivalent to 10 mg oxycodone HCl) 13.5mg (equivalent to 15 mg oxycodone HCl) 18mg (equivalent to 20 mg oxycodone HCl) 27mg (equivalent to 30 mg oxycodone HCl) 36mg (equivalent to 40 mg oxycodone HCl) Abuse-deterrent capsule utilizing DETERx technology platform to maintain its extended-release profile after being subjected to common methods of tampering oral concentrate: Schedule II 20mg/mL oral solution: Schedule II 5mg/5mL MORE... Moderate-to-Severe Pain Immediate-release Opioid-tolerant:: 10-30 mg PO q4-6hr Opioid-naïve (initial dose): 5-15 mg PO q4-6hr Chronic Severe Pain Controlled-release products (eg, OxyContin, Xtampza ER) are indicated for the management of pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate.
Also see Administration
Initial dosing OxyContin Opioid-naïve patients: 10 mg PO q12hr initially; titrate gradually every 1-2 days, increasing by 25-50% increments, with q12hr dosing interval maintained A single dose >40 mg ER or total dose >80 mg ER are for use only in opioid-tolerant patients Xtampza ER Opioid-naïve patients: 9 mg PO q12hr with food Dosage Modifications Coadministration with other CNS depressants: Initiate long-acting oxycodone with one-third to one-half the recommended starting dose; monitor for signs of respiratory depression, sedation, and hypotension.
Conversion from other opioids to OxyContin
Provide immediate-release opioids for breakthrough pain Monitor patient closely for adverse effects or breakthrough pain during conversion and for several days following Also see Medscape reference topic - Opioid Equivalents Conversion from other oral oxycodone formulations Conversion from other oral oxycodone formulations: Administer one-half of the patient's total daily PO oxycodone dose as q12hr Conversion from fentanyl transdermal: Wait 18 hr after patch removed, then initiate conservative dose of ~10 mg q12hr oxycodone controlled-release for each 25 mcg/hr fentanyl transdermal patch Conversion from fentanyl transdermal Wait 18 hr after patch removed, then initiate conservative dose of ~10 mg q12hr oxycodone controlled-release for each 25 mcg/hr fentanyl transdermal patch Conversion from other opioids to Xtampza ER Conversion from other oral oxycodone formulations Administer one-half of the patient's total daily PO oxycodone dose as q12hr with food Because Xtampza ER is not bioequivalent to other oxycodone extended-release products Monitor patients for possible dosage adjustment Conversion from other opioids Discontinue all other around-the clock opioid drugs There are no established conversion ratios for conversion from other opioids to Xtampza ER defined by clinical trials Initiate dosing using 9 mg PO q12hr with food and provide immediate-release rescue medication while stabilizing patient on Xtampza ER Conversion from methadone Close monitoring is of particular importance when converting from methadone to other opioid agonists; the ratio between methadone and other opioid agonists may vary widely as a function of previous dose exposure and methadone has a long half-life and can accumulate in the plasma Conversion from fentanyl transdermal 18 hr following the removal of the transdermal fentanyl patch, initiate Xtampza ER; there has been no systematic assessment of such conversion, a conservative oxycodone dose, ~9 mg (equivalent to 10 mg oxycodone HCl) q12hr should be initially substituted for each 25 mcg/hr fentanyl transdermal patch Renal impairment CrCl <60 mL/min: Serum concentration may increase by 50%; adjust dosage to response Hepatic impairment Reduce dosage in liver disease; decrease dosage of extended-release form to 1/3 or 1/2 of usual starting dosage; titrate to response Alternative analgesics are recommended for patients who require a dose of Xtampza ER <9 mg Dosing Considerations Access to naloxone for opioid overdose Assess need for naloxone upon initiating and renewing treatment Consider prescribing naloxone Based on patient’s risk factors for overdose (eg, concomitant use of CNS depressants, a history of opioid use disorder, prior opioid overdose); presence of risk factors should not prevent proper pain management Household members (including children) or other close contacts at risk for accidental ingestion or overdose Consult patients and caregivers on the following: Availability of naloxone for emergency treatment of opioid overdose Ways differ on how to obtain naloxone as permitted by individual state dispensing and prescribing requirements or guidelines (eg, by prescription, directly from a pharmacist, as part of a community-based program).
Discontinuation
Use a gradual downward titration of the dosage to avoid signs and symptoms of withdrawal in the physically-dependent patient Do not abruptly discontinue Xtampza ER Opioid-tolerant definition Use of higher starting doses in patients who are not opioid tolerant may cause fatal respiratory depression Patients who are opioid tolerant are those receiving, for 1 week or longer, at least 60 mg/day PO morphine, 25 mcg/hr transdermal fentanyl, 30 mg/day PO oxycodone, 8 mg/day PO hydromorphone, 25 mg/day PO oxymorphone, or an equianalgesic dose of another opioid Limitations of use Because of the risks of addiction, abuse, and misuse with opioids, even at recommended doses, and because of the greater risks of overdose and death with extended-release opioid formulations, reserve for patients whom alternative treatment options (eg, nonopioid analgesics or immediate-release opioids) are ineffective, not tolerated, or would be otherwise inadequate to provide sufficient management of pain Long-acting opioids are not indicated as a PRN analgesic.
0 Comments
Leave a Reply. |
Details
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |